Andy Murray will be hoping to replicate the success of fellow British star Johanna Konta when he plays for a place in Wimbledon's semi-finals.
Murray will take on American Sam Querrey first on Centre Court in his tenth quarter-final at the tournament.
The clash comes one day after Konta became the first British woman to make it to the semi-finals of Wimbledon since Virginia Wade in 1978.
The British tennis star held her nerve in a nail-biting three-set match against world number two Simona Halep, coming from one set down to win 6-7 7-6 6-4.
Wade, who was also the last British woman to lift the Wimbledon trophy in 1977, watched on from the Royal Box and said she was "ultra-impressed" by Konta's performance.
Men's singles title favourite Roger Federer will take to Centre Court second on Wednesday in his quarter-final against Milos Raonic.
On Court One, Novak Djokovic will face Tomas Berdych and beforehand Gilles Muller will play Marin Cilic.
Elsewhere, home fans could have reason to cheer when Heather Watson and Finnish partner Henri Kontinen continue their defence of the mixed doubles title on Court Two.
Players and spectators will be hoping for drier weather after a soggy day at the Championships on Tuesday.
Matches were suspended throughout the day on outside courts before play was abandoned completely in the early evening.
It has been a history-making tournament for British pair Murray and Konta.
Their joint success in the fourth round on Monday marked the first time a British man and woman have made it through to the quarter-finals since Roger Taylor and Virginia Wade in 1973.
If Murray also wins a place in the semi-finals on Wednesday, it will be the first time since 1967 Britain has had a man and a woman in the last four of the singles.
Crowds flocking to SW19 to watch Murray in action will enjoy a dry day with sunny spells after morning drizzle clears, the Met Office said.
Highs of 23C (73F) are expected.
Olympic champion cyclist Sir Chris Hoy will be among those in the Royal Box on Centre Court, joined by actors Sir Mark Rylance, Sir Ian McKellen and Dame Maggie Smith.