Manchester Royal Infirmary has closed its accident and emergency department while it investigates two patients with suspected Middle Eastern Respiratory Virus Syndrome (Mers).
Both patients have been isolated for ongoing clinical treatment and management of their condition, Central Manchester University Hospitals NHS Foundation Trust said.
"We would like to reassure our patients and the general public that there is no significant risk to public health," the statement said.
"Manchester Royal Infirmary accident and emergency department will be closed until further notice while further investigations take place."