David Cameron has condemned the "evil" murder of 49 people in the Pulse gay club in Orlando.
Speaking during prime minister's questions on Wednesday, Cameron said he sent his "profound sympathies to the family and friends" of those who died.
"This was an evil attack of terrorism and homophobic hatred and we utterly condemn both of them.
"This attack, along with callous murder of French police couple on Monday is a stark reminder of the challenge we face to defeat the poisonous ideology of Daesh both online and on our streets."
Jeremy Corbyn, who joined a vigil in Soho in central-London on Monday evening, said he shared the prime minister's sentiment.
"I want to say thank you all over this country who attended vigils all over the country to show their concern and their horror," he told MPs.
Corbyn, education secretary Nicky Morgan, London Mayor Sadiq Khan, Scottish Conservative leader Ruth Davidson and other politicians joined the vigil in Soho.