Launching on 3 November, the collection will span womenswear, menswear and accessories - and it promises to bring the "spirit of Kenzo" to the high street.
Previous H&M collaborations with Balmain, Alexander Wang and Karl Lagerfeld were all met with huge success.
"With this collaboration with H&M we want to think big, push the boundaries and bring the new energy of Kenzo to everyone around the world," said Kenzo creative directors Carol Lim and Humberto Leon in an official statement.
"We can't wait to share with everyone the world of Kenzo x H&M, with all of its creativity, fun and love of fashion," added Ann-Sofie Johansson, creative advisor at H&M.
KENZO x H&M will be available in over 250 selected H&M stores worldwide, as well as online, from 3 November 2016.
