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They previously gave a shout-out to Jesy during their scene-stealing acceptance speech.
From incredible performances and hilarious sketches, to poignant speeches and political statements.
Little Mix made history with their Best British Group win, and there were also prizes for Harry Styles, Arlo Parks and Billie Eillish.
"We all support a fair pay rise for our front line," the Don't Start Now singer said.
Dua Lipa, Billy Porter, Maya Jama and Griff are just some of the stars who wowed.
NBC has also announced it will not be broadcasting next year's ceremony.
The Little Mix singer has said she's "never felt so empowered" since sharing her own experiences of racism.
The chart-topping singer and her footballer boyfriend Alex Oxlade-Chamberlain are expecting their first child.
The Deadpool actor shared a typically cheeky message.
"I was totally off the rails".